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2024-03-07 18:24:49

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综试区-跨境服务_跨境平台-E揽全球（eBox）创新项目服务平台

暂无图片跨境洞察全球GMV概况

2022年全球GMV

8161

亿美元

平均每件货物销售价

31.53

美元全球大卖家情况

全球大卖数量

4520

家

全国大卖数量

1240

家全国跨境电商概况

2022年出口零售

1633

亿美元

全国卖家数量

64.1

万家全省主流跨境电商概况

B2C平台卖家数量

14.6

万家

GMV值

257.93

亿美元中国跨境电商卖家数TOP3

广东省

万家

浙江省

万家

福建省

万家

北京

2024年03月07日 18 : 24 : 12

华盛顿

2024年03月07日 05 : 24 : 12

东京

2024年03月07日 19 : 24 : 12

伦敦

2024年03月07日 10 : 24 : 12

柏林

2024年03月07日 11 : 24 : 12

渥太华

2024年03月07日 05 : 24 : 12

马德里

2024年03月07日 11 : 24 : 12

巴黎

2024年03月07日 11 : 24 : 12 实时汇率（更新时间：）【数据仅供参考，交易时以银行柜台成交价为准】跨境工具报关单验真查询进口商品检测报告

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货物信息： +新增货物信息长:cm 宽:cm 高:cm 重量:kg 同尺寸重:箱特殊物品： ! 违禁品说明运输方式：批量发货 > 重置全网查价海外征信基础信用报告深度调研报告风险评估报告全球风险热力图基础信用报告深度调研报告

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生态服务

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通关服务

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物流仓储

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数据分析

人才培育

其他服务

杭州集酷信息技术有限公司

KiKUU

联系人：KiKUU 简介：非洲跨境电商平台，筑梦"一带一路"，集酷连接非洲与中国，成立于2015年，诞生于非洲，致力于帮助中国卖家开拓面向非洲的B2B和B2C业务。我要预约在线预约

Colibri SAS

ManoMano

联系人：俞俊强简介：ManoMano创立于2013年，是欧洲首家/法国最大家居园艺垂直电商平台，覆盖法德英西意比六国，有7百万活跃用户、5千万月独访问，热销工具、室内外家具、厨房卫浴、灯具照明等品类，深受本土消费者青睐。2021年ManoMano完成3.55亿美元F轮融资，跻身独角兽企业。我要预约在线预约

维鑫友信息科技（郑州）有限责任公司

Starday

联系人：姚国平简介： Starday，中文含义星曜。日本跨境电商平台新秀，源于2017年，盛于2019年！从最初只有自行车和户外两个类目迅速扩大至全品类！短短几年时间已经跻身日本电商平台头部品牌，影响力日渐突出！

平台2019年开始在国内招募商家入驻，充分结合日本的市场优势和国内的货源优势，让国内优质产品避免内卷顺利出海！在国内经历几年的探索，已整合出既适合中国国情，又适应当前国际贸易形式的电商产业链条！

目前平台已经形成仓储——中国国内中转仓和日本海外仓两大仓储中心，自建——“Starday急便”物流，对接合作——airwallex三方支付产业全链条，真诚服务于国内商家的入驻和经营！

平台初步计划在2025年前，择机开通欧洲站和美国站，届时将真正实现货通全球实惠到家的平台定位，为平台的商家创造更多商机！我要预约在线预约

Gmarket&Auction

联系人：扫码入驻简介：Gmarket——成立于2000年，作为韩国最具代表性的TOP级综合电商平台，其使用人数覆盖韩国总人口的64%，拥有超600w的月访客量，位居全韩第二

Auction——成立于1998年，是韩国历史上第一个电商平台，也是韩国排名第一的电商拍卖行，已成为韩国主流综合型电商平台之一

2021年，韩国第一大零售商新世界集团易买得(emart)收购平台后，集团线上平台在韩国电商平台销售占比中排名第二

2022年，emart在中国设立跨境业务部，开始面向中国卖家开展业务并邀请部分卖家入驻

2023年，正式对外招募商家我要预约在线预约

ebox_百度百科

_百度百科网页新闻贴吧知道网盘图片视频地图文库资讯采购百科百度首页登录注册进入词条全站搜索帮助首页秒懂百科特色百科知识专题加入百科百科团队权威合作下载百科APP个人中心收藏查看我的收藏0有用+10ebox播报上传视频一种无线互联网点播设备ebox是一种无线互联网点播设备，其采用先进的DLNA结构，并优化P4P传输结构，采用云技术作为分布式数据处理。也是联想公司生产的一款游戏机的名字。中文名ebox正式发布2011年5月6日下午含义一种无线互联网点播设备处理技术云技术连结DLNA结构目录1设备介绍2联想产品3汽车设备4网络软件设备介绍播报编辑于2011年5月6日下午，联想控股成员企业北京联合绿动科技有限公司(以下简称联合绿动)历时2年多研发的，此前研发代号为“eBox”的3D人体动作交互游戏机，正式发布，并正式更名为iSec，中文名称“爱赛客”.联合绿动相关人士表示，目前该主机共有白、黒、红三色可选，计划2011年下半年在中国大陆上市。目前已有独占游戏十余款. 可以连接到电视机上，使电视机可以点播高清影视节目。可以连接到电视机上，使电视机可以点播高清影视节目。同时采用802.11gWi-Fi无线网络连接，具有相当的灵活性。其输出支持HDMI1.3，可支持高清视频。节目内容每天更新，并不收取任何服务费。华硕Ebox联想产品播报编辑由联想集团、联想控股和联想投资共同投资建立的北京联合绿动科技有限公司宣告成立，主要提供3D全身动作识别家庭游戏机产品eBox，预计2010年11月份发布，2011年正式上市销售。　2010年8月9日，联合绿动公司在北京成立，eedoo联合绿动公司作为联想控股成员企业，由联想集团公司、联想控股公司和联想投资公司共同投资建立。联合绿动内部人士对新浪科技确认了上述消息，并透露公司也在积极引入更多游戏，以丰富eBox游戏平台。该人士表示，eBox正式上市的时间目前来看应该还是在2011年第一季度，并不会延迟太久。该人士还透露，联合绿动的高管最近一直在与合作伙伴进行商务层面以及技术层面的谈判，其中政府关系方面也有很重要的进展。不过他拒绝透露具体细节。据了解，通过eBox产品，使用者不靠手柄或者遥控器等任何设备，只需摄像头，即可与电视3D游戏形成互动。这一游戏设备与微软研发的Kinect体感游戏设备类似。联想Ebox即将上市ebox中国正在进行前所未有的三网融合，因此会产生一部分产品，Ebox是联想集团投资的北京联合绿动科技公司面向"三网融合"的数字家庭产品项目，投入巨资历时近两年自主研发的产品，你现在在上图看到的就是长的样子，号称采用了3D全身动作识别及交互技术、在线动作交互游戏技术、嵌入式软件及应用技术、T+S云计算软件技术、芯片级软件加密技术；也就是说，这是中国版的Kinect，目前还没有更多的消息，游戏类别应该和WII的差不多，但是游戏种类，游戏的可玩性，持续的游戏供应还不得而知。联想控股旗下游戏公司联合绿动日前悄然启动渠道招募工作，并且公开招聘渠道市场推广经理。这一举动意味着，联合绿动研发的3D人体动作交互游戏机eBox已经上市在即。26日，联合绿动在公司网站显著位置打出渠道商招募通知。根据招募页面显示，渠道商加盟除了需要填写公司基本信息外，“预计ebox运营资本”也作为一条重要信息单列出来。联合绿动由联想集团、联想控股和联想投资共同投资建立，该公司主要提供3D全身动作识别家庭游戏机产品eBox。联合绿动相关人士接受新浪科技连线时表示，“公司对于渠道商的选择非常谨慎，会全面考量渠道商的资金规模、公司所处行业、营业店面等。”该人士表示，虽然渠道招募工作刚刚开始，但已经有一些公司提交了加盟申请。他没有透露具体数字。在招募渠道商的同时，联合绿动也开始招聘渠道推广人员。据智联招聘公布的职位信息显示，联合绿动正在招募一名渠道市场推广经理，并要求全面负责公司产品推广目标，建立、并完善渠道市场推广体系等工作。联合绿动曾计划2010年11月份正式发布eBox，但在11月底，官方宣布推迟发布。联合绿动当时表示，推迟主要是因为“用户体验的细节还需要进一步优化”。联合绿动相关人士今天透露，公司内部专家组在上周对eBox进行了内部评审，按照公司内部制定的考核标准，评审结果很不错，“不过eBox的最终上市时间仍然没有敲定”。据了解，通过eBox产品，使用者不靠手柄或者遥控器等任何设备，只需摄像头，即可与电视3D游戏形成互动。这一游戏设备与微软研发的Kinect体感游戏设备类似。微软公布的数据显示，Kinect上市60天内已售出800万套。汽车设备播报编辑用水作为能源，用电解的方式得到两个氢一个氧，能够使发动机烧更少的油，得到百分之三十八的节油率，其实早在几百年前，许多学者、许多科学家他们打算开发，为什么？因为水是非常多的，占我们地球最多的就是水，超过百分之七十以上的，那水这个物体经过使用之后，它又可以再还原，是一种梦寐以求的能量，你只需要少量的水，然后再插入这个电解片，那么导入电源，正电源、负电源、直流电源，然后你就会看到很多气体、气泡开始产生，所以这些气泡就是我们所谓的氢和氧，这个气泡你可以直接点燃。早在1982年的时候，很多文献里边已经证明说汽油加氢之后，增加燃点、增加爆发力、增加扩展力，的确能够使发动机烧更少的油，也能够降低百分之九十八的尾气排放，这的确是存在的、可行的，当你安装上这个ebox的时候，你可以得到的功效，就是更强大的动力，你的车、油门就更轻，里边的燃烧完整了，积碳就会被清除，所以就会延长我们的发动机的寿命，减少我们的维修，当然最后没有噪音，所以你会觉得你的车不只是动力强，声音都特别静，开起来特别舒服，好像开新的车一样。根据2010年1月18日的统计，中国的汽车保有量，已经达到七千六百二十万辆，我们就打一个比方说按照七千六百二十万辆的，中国汽车保有量作一个计算，如果只要我们能够节油率百分之五，也意味着每一天我们能够减少三百八十万台车的排量，那么我们今天也知道全球的汽车保有量已经达到八亿台了，你可以想想那个排放有多少呢？那个市场又有多大呢？而且这不是全部，因为使用发动机、内燃机的我们还有工业车、农业车，大型的重型机械车，还有军用车，还有海面上的、天空上飞的，甚至我们还可以烹饪，发电机、烧焊的、切割的，甚至还有其他种种的有待大家去开发，目前我们这个技术已经跟清华大学研究院这边已经进行合作。ebox裕宝伟业“ebox”为裕宝伟业集团（国际）品牌机构旗下创意电脑装备品牌，授权裕宝伟业集团（中国）有限公司负责亚太地区（含大中华地区）区域内的ebox品牌及产品的运营管理。ebox品牌创意电脑装备设计，由裕宝伟业集团（国际）品牌机构旗下的纽约、伦敦、米兰、巴黎4大世界创意工作室完成，创意同步世界！　EBOX品牌所有产品造型及创意专利及相关知识产权全部为裕宝伟业集团（国际）品牌机构所有。Ebox以其其全球化创意设计团队整合FIFA（足球世界杯品牌全球运营商）、WB（电脑周边产品授权商）两大消费品牌资源，同步集结全球领先创意，领航全球创意电脑装备市场！1997年，ebox品牌诞生，开始其全球化布局！迄今，Ebox品牌分支机构及产品已经遍布欧洲、美洲、亚洲、大洋洲等数十个国家级地区，2005年，裕宝伟业集团（中国）有限公司携手DISNEY迪斯尼（亚太区电脑周边产品授权商）、WB华纳（电脑周边产品授权商）进入中国。开创了中国创意电脑周边产品之先河，成为大中华区创意电脑周边产品行业冠军品牌！ebox在手网络软件播报编辑ebox网易网盘助手网盘助手是网易邮箱推出的一款网易邮箱网盘的支持工具。您可以用网盘助手使一个本地电脑的文件夹和网易邮箱网盘中的文件夹进行绑定，成为同步文件夹。绑定成功后，无论是添加文件、修改文件内容，两个同步文件夹之间均可进行同步。新手上路成长任务编辑入门编辑规则本人编辑我有疑问内容质疑在线客服官方贴吧意见反馈投诉建议举报不良信息未通过词条申诉投诉侵权信息封禁查询与解封©2024 Baidu 使用百度前必读 | 百科协议 | 隐私政策 | 百度百科合作平台 | 京ICP证030173号京公网安备110000020000

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宜堡斯EBOX箱包科技公司始创于1999年，总部设立中国广州白云区江高工业园，距广州白云国际机场19KM，广州工厂和湖南工厂共有600多员工，20年发展专注定位——创建数码商务箱包国际知名品牌，服务全球客户和品牌营销，公司尊重客户和以市场为导向，注重团队人才培养，打造工匠精神，精英设计研发人才众多，公司综合实力位于中国商务箱包行业前茅。

公司产品定位分类：商务箱包、数码箱包、时尚箱包、休闲箱包、旅行生活型箱包、登山包、功能类箱包、礼品类箱包、PU包和皮具男女包、商务拉杆包等；公司生产能力超强承接ODM和OBM全球订单；公司特优势：1、创意设计能力信息最前瞻，资讯来自全球高效配合客户深入耕耘市场；2、最严品控管理流程，QC质量管理系统完善，品质稳定；3、本行业内坚持交期最准、最短交货；4、同行业内产品最优性价比，同品质最低价位。长期合作欧美及全球大品牌客户、大卖场、连锁品牌客商、中大型进口贸易商、网络平台及线上品牌客户。

公司通过ISO9001认证、BSCI认证、产品REACH、LOSE和CE认证；配合客户经常性综合验厂。创新、品质、高效、服务是我司坚持的管理理念。

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IDEAL

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Bag ∙ Created the top ten international creative brands

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MISSION

包 ∙ 在行走间感受便捷、显潮尚！

Bag ∙ Feel the convenience and fashion when walking!

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MANAGEMENT CONCEPT

创新+创意+品质+体验感传递价值

Innovation+Creativity+Quality+Customer experience Deliver Value

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TEAM WORK

专注目标！每天进步1%！我尊重、我快乐、我行动、我收获！Focus on the goal! Make progress by 1% every day! I respect, I am happy, I act, I gain!

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Partners are deeply involved in 139 countries around the world

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eBox开发板：简化STM32编程的物联网开发板

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eBox-SPARK开发板是一款可直接编程的STM32开发板，让STM32的编程开发变得同Arduino编程一样简单。是什么利器能让STM32编程如此简单呢？答案就是eBox-SPARK开发板上所运行的系统eBox！eBox是什么eBox是一个运行在STM32平台上的软硬件一体化的解决方案和开发平台，涵盖了STM32外设层、芯片驱动层、系统层、标准应用软件层、用户软件层和bootloader。eBox寓意简单的盒子，彻底简化STM32编程！把“拿来主义”贯彻到底！我与eBox的故事自己在经历过这些各种项目，很多都是用STM32系列单片机作为主控来实现的，虽然代码写了很多，但是总觉得每次做项目都要花很长时间调试驱动，即使网上有网友写的驱动可以下载，但是肯定要改很多地方才能使用，经常没那么顺利，导致在调试的过程中要不断的在检查硬件和检查软件的死循环中。难道是我能力有限，还是方法不对？在想了很久之后，萌生了一个想法，就是让单片机的开发驱动规范化，简单化，让用户像装Windows驱动一样，下载安装即可。这样我在保证我硬件连接没有问题的情况下，驱动就可以很快的调试通过，可以节约我大量的时间来处理应用层的逻辑事物。eBox就应运而生了。当然经过不断的改进ebox不仅仅提供了标准的驱动层，还有跟多标准的服务组件，可以满足用户的快速开发。我对STM32编程的思考脱胎换骨，再度归来第一次众筹结束后，eBox增加了众多粉丝，他们也加入到了开发行列中，为eBox增添了很多功能。包括驱动库、标准软件等等。为了更方便用户的测试使用，我又开发了一个拓展版，可以让用户一个板子在手，就可以做所有的外设实验，这就是IOT拓展版。他支持了WIFI 、EEPROM、FLASH、CAN、485、LCD、RGB彩灯、温湿度、红外接收头、红外发射管等等功能，配套的软件也已经做好了。用户可以真正体验eBox编程带来的乐趣和极致的体验！我们在做的绝不是一个简单的开发板！而是为所有工程师搭建一个完美的软件和硬件开发平台，成为工程师最好的助手，成为新手入门STM32最快的捷径！敢于抛弃传统，才能走向未来！eBox开发平台适合哪些人？电子、计算机相关专业开始学习STM32的同学从事STM32开发的工程人员想实现STM32快速项目开发的工程人员所有支持国产嵌入式操作系统发展的志同道合的同志支持eBox开发平台可以获得什么？一套eBox开发板（包括STM32核心板、拓展版<带显示屏和wifi功能>、下载调试器）eBox开发教程，电路图eBox现有的开源驱动、标准应用、操作系统代码eBox软件生态系统中所有开发者共享的开源代码快速进行STM32编程开发的方法良好的编程习惯和代码框架设计eBox固件库优势eBox固件库使用c++的方式封装了STM32的固件库，给用户呈现一个非常简单的应用接口。让用户无需再去详细阅读芯片手册，也无需详细了解官方复杂的固件库函数。只要知道eBox的API即可完成你想要的功能。让STM32也能像Arduino一样方便的编程。▲完美标准程序框架 ▲全面的外设支持，人性化API接口，简化编程。重新定位API接口，抛弃传统的思路，站在用户的角度去设计接口，比如PWM以频率和占空比参数初始化；定时器以中断频率为参数初始化；串口以波特率为参数进行初始化；SPI以MODE0/1/2/3、速度、数据大小端为参数初始化I2C以速度为参数初始化，这样一来用户使用起来就非常简单。外设固件库列表●数字IO，PA0-PG15所有引脚●支持任意8位IO分组，方便总线类型器件编程●ADC1的16个通道，CH1-16●通用定时器TIM2、3、4、5、6、7的定时中断●高级定时器TIM1的定时中断●12路PWM●12路输入捕获通道●16通道的外部中断，可影射所有引脚●硬件SPI1、2、3●硬件I2C1、2●软件SPI，支持任意IO配置●软件件I2C，支持任意IO配置●串口，支持USART1、2、3、4、5●实时时钟RTC●内部flash编程●独立看门狗●CAN控制器●USB控制器 ▲开源共享驱动，解决移植大问题用户可以通过eBox官方渠道获取免费已有开源驱动程序，基于eBox的标准驱动加载到本地工程后，文件不需要任何修改、用户只需在应用层创建芯片对象的时候重新填写自己的硬件接口就可以使用。驱动就像一个黑盒子，用户不用关心如何实现，只需调用其公共接口即可。增加了驱动代码的复用率，大大降低了驱动移所占用的时间。驱动库（新增部分）：●1.8寸LCD显示器驱动●W25X16系列spi flash存储芯片驱动●AT24C02存储芯片驱动●WIFI驱动●485总线●can总线●红外发射●红外接收●DHT11温湿度●更多驱动程序不再一一列举 ▲标准应用库的建立标准应用程序就是解决通用或者特定领域内的一些标准程序，统一其编程规范和接口，争取以后可以做到让用户一看函数名称就能知道怎么使用。应用层（部分新增）●网络应用程序●文件系统FATFS●modbus●WIFI网络应用层●高级日历程序●色彩转换控制器●增加了很多系统功能函数和用户常用函数▲操作系统eBox目前支持三个操作系统ucos、freertos这两个系统在嵌入式领域占有绝对重量的地位。ebox_os是自主开发的一个小型操作系统，包含了任务调度、挂起、唤醒等简单的功能，操作系统完全开源，也是用户学习操作系统原理的典型例子。●支持eBox_OS●支持UCOS●支持FreertOS中国梦——EBOX软件生态系统的建立目前已经有很多用户开始使用eBox固件库进行开发，他们也在不断的共享驱动库、应用程序，其中包括CAN驱动、modbus驱动、OLED驱动、USB驱动、SD卡bug修正、WiFi驱动等等，在不久的以后会有更多用户贡献更多的代码，让大家体验到软件生态系统的真正强大之处。整个生态系统的发展需要大家共同的努力。大家不断的共享出更优秀的代码eBox才能发展的更快。至此，我要感谢大家的无私奉献，感谢你们为国人固件库的发展支持，能真正的参与eBox生态系统的发展。

常见问题

本次的版本和第一次众筹的版本有哪些改变？

硬件上对主板进行了重新布局并增加传感器，同时新增扩展版带显示屏和WiFi功能。软件上完善驱动库。

09日

06月

【eBox二期众筹结束】公开资料、发货通知、抽奖记录

eBox二期众筹已经结束了。首先要感谢大家对ebox的支持！也感谢电子发烧友平台给我的大力支持。这一期的效果明显没有达到预期目标，主要原因在于我这段时间比较忙，没办法经常跟大家沟通交流，发帖跟进。但是为了不让大家失望，我还是决定给大家发货。

09日

05月

eBox开发板教程：教你如何开挂一般上手编程STM32（连载二）

讲解eBox核心固件库的所有芯片级外设的封装接口和使用方法。包含了GPIO、UART、EXIT、ADC、TIMER、INCAPTURE、FLASH、IDWG、RTC、SYS、CAN等基础外设。

05日

05月

eBox开发板教程：教你如何开挂一般上手编程STM32(连载一)

主要介绍eBox固件库及教程与指南的配合使用，并对eBox三个组件的功能及板卡细节介绍，以电路形式讲解eBox三个组件中各个模块作用及如何实现功能

常见问题

1、本次的版本和第一次众筹的版本有哪些改变？

硬件上对主板进行了重新布局并增加传感器，同时新增扩展版带显示屏和WiFi功能。软件上完善驱动库。

还可以输入200个字

相关问题的答复会发送到账户绑定邮箱和站内私信哟~

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2016-05-06

这个进度有点慢啊！这个是不是已经开发完了？众筹不成功应该可以直接购买吧？

hitzhxy:淘宝是一代的吧(2016-05-10)

A670521546:这个是最新的一代(2016-05-09)

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E-box - Wikipedia

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(Top)

1Discovery

2Binding

3Role in the circadian clock

4Role of proteins which bind to E-boxes

Toggle Role of proteins which bind to E-boxes subsection

4.1CLOCK-ARNTL complex

4.2MYC (c-Myc, an oncogene)

4.3MYOD1 (MyoD)

4.4MyoG (Myogenin)

4.5TCF3 (E47)

5Recent research

6References

7External links

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From Wikipedia, the free encyclopedia

DNA response element in some eukaryotes

An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues.[1] Its specific DNA sequence, CANNTG (where N can be any nucleotide), with a palindromic canonical sequence of CACGTG,[2] is recognized and bound by transcription factors to initiate gene transcription. Once the transcription factors bind to the promoters through the E-box, other enzymes can bind to the promoter and facilitate transcription from DNA to mRNA.

Discovery[edit]

The E-box was discovered in a collaboration between Susumu Tonegawa's and Walter Gilbert's laboratories in 1985 as a control element in immunoglobulin heavy-chain enhancer.[3][4] They found that a region of 140 base pairs in the tissue-specific transcriptional enhancer element was sufficient for different levels of transcription enhancement in different tissues and sequences. They suggested that proteins made by specific tissues acted on these enhancers to activate sets of genes during cell differentiation.

In 1989, David Baltimore's lab discovered the first two E-box binding proteins, E12 and E47.[5] These immunoglobulin enhancers could bind as heterodimers to proteins through bHLH domains. In 1990, another E-protein, ITF-2A (later renamed E2-2Alt) was discovered that can bind to immunoglobulin light chain enhancers.[6] Two years later, the third E-box binding protein, HEB, was discovered by screening a cDNA library from HeLa cells.[7] A splice-variant of the E2-2 was discovered in 1997 and was found to inhibit the promoter of a muscle-specific gene.[8]

Since then, researchers have established that the E-box affects gene transcription in several eukaryotes and found E-box binding factors that identify E-box consensus sequences.[9] In particular, several experiments have shown that the E-box is an integral part of the transcription-translation feedback loop that comprises the circadian clock.

Binding[edit]

E-box binding proteins play a major role in regulating transcriptional activity. These proteins usually contain the basic helix-loop-helix protein structural motif, which allows them to bind as dimers.[10] This motif consists of two amphipathic α-helices, separated by a small sequence of amino acids, that form one or more β-turns. The hydrophobic interactions between these α-helices stabilize dimerization. Besides, each bHLH monomer has a basic region, which helps mediate recognition between the bHLH monomer and the E-box (the basic region interacts with the major groove of the DNA). Depending on the DNA motif ("CAGCTG" versus "CACGTG") the bHLH protein has a different set of basic residues.

Relative Position of CTRR and E-Box

The E-box binding is modulated by Zn2+ in mice. The CT-Rich Regions (CTRR) located about 23 nucleotides upstream of the E-box is important in E-box binding, transactivation (increased rate of genetic expression), and transcription of circadian genes BMAL1/NPAS2 and BMAL1/CLOCK complexes.[11]

The binding specificity of different E-boxes is found to be essential in their function. E-boxes with different functions have a different number and type of binding factor.[12]

The consensus sequence of the E-box is usually CANNTG; however, there exist other E-boxes of similar sequences called noncanonical E-boxes. These include, but are not limited to:

CACGTT sequence 20 bp upstream of the mouse Period2 (PER2) gene and regulates its expression[13]

CAGCTT sequence found within the MyoD core enhancer[14]

CACCTCGTGAC sequence in the proximal promoter region of human and rat APOE, which is a protein component of lipoproteins.[15]

Role in the circadian clock[edit]

The link between E-box-regulated genes and the circadian clock was discovered in 1997, when Hao, Allen, and Hardin (Department of Biology at Texas A&M University) analyzed rhythmicity in the period (per) gene in Drosophila melanogaster.[16] They found a circadian transcriptional enhancer upstream of the per gene within a 69 bp DNA fragment. Depending upon PER protein levels, the enhancer drove high levels of mRNA transcription in both LD (light-dark) and DD (constant darkness) conditions. The enhancer was found to be necessary for high-level gene expression but not for circadian rhythmicity. It also works independently as a target of the BMAL1/CLOCK complex.

The E-box plays an important role in circadian genes; so far, nine E/E'BOX controlled circadian genes have been identified: PER1, PER2, BHLHB2, BHLHB3, CRY1, DBP, Nr1d1, Nr1d2, and RORC.[17] As the E-box is connected to several circadian genes, it is possible that the genes and proteins associated with it are "crucial and vulnerable points in the (circadian) system."[18]

The E-box is one of the top five transcription factor families associated with the circadian phase and is found in most tissues.[19] A total of 320 E-box-controlled genes are found in the SCN (suprachiasmatic nucleus), liver, aorta, adrenal, WAT (white adipose tissue), brain, atria, ventricle, prefrontal cortex, skeletal muscle, BAT (brown adipose tissue), and calvarial bone.

E-box like CLOCK-related elements (EL-box; GGCACGAGGC) are also important in maintaining circadian rhythmicity in clock-controlled genes. Similarly to the E-box, the E-box like CLOCK related element can also induce transcription of BMAL1/CLOCK, which can then lead to expression in other EL-box containing genes (Ank, DBP, Nr1d1).[20] However, there are differences between the EL-box and the regular E-box. Suppressing DEC1 and DEC2 has a stronger effect on E-box than on EL-box. Furthermore, HES1, which can bind to a different consensus sequence (CACNAG, known as the N-box), shows suppression effect in EL-box, but not in E-box.

Both non-canonical E-boxes and E-box-like sequences are crucial for circadian oscillation. Recent research on this forms an hypothesis that either a canonical or non-canonical E-box followed by an E-box like sequence with 6 base pair interval in between is a necessary combination for circadian transcription.[21] In silico analysis also suggests that such an interval existed in other known clock-controlled genes.

Role of proteins which bind to E-boxes[edit]

There are several proteins that bind to the E-box and affect gene transcription.

CLOCK-ARNTL complex[edit]

The CLOCK-ARNTL (BMAL1) complex is an integral part of the mammalian circadian cycle and vital in maintaining circadian rhythmicity.

Knowing that binding activates transcription of the per gene in the promoter region, researchers discovered in 2002 that DEC1 and DEC2 (bHLH transcription factors) repressed the CLOCK-BMAL1 complex through direct interaction with BMAL1 and/or competition for E-box elements. They concluded that DEC1 and DEC2 were regulators of the mammalian molecular clock.[22]

In 2006, Ripperger and Schibler discovered that the binding of this complex to the E-box drove circadian DBP transcription and chromatin transitions (a change from chromatin to facultative heterochromatin).[23] It was concluded that CLOCK regulates DBP expression by binding to E-box motifs in enhancer regions located in the first and second introns.

MYC (c-Myc, an oncogene)[edit]

MYC (c-Myc), a gene that codes for a transcription factor Myc, is important in regulating mammalian cell proliferation and apoptosis.

In 1991, researchers tested whether c-Myc could bind to DNA by dimerizing it to E12. Dimers of E6, the chimeric protein, were able to bind to an E-box element (GGCCACGTGACC) which was recognized by other HLH proteins.[24] Expression of E6 suppressed the function of c-Myc, which showed a link between the two.

In 1996, it was found that Myc heterodimerizes with MAX and that this heterodimeric complex could bind to the CAC(G/A)TG E-box sequence and activate transcription.[25]

In 1998, it was concluded that the function of c-Myc depends upon activating transcription of particular genes through E-box elements.[26]

MYOD1 (MyoD)[edit]

MyoD comes from the Mrf bHLH family and its main role is myogenesis, the formation of muscular tissue.[9] Other members in this family include myogenin, Myf5, Myf6, Mist1, and Nex-1.

When MyoD binds to the E-box motif CANNTG, muscle differentiation and expression of muscle-specific proteins is initiated.[27] The researchers ablated various parts of the recombinant MyoD sequence and concluded that MyoD used encompassing elements to bind the E-box and the tetralplex structure of the promoter sequence of the muscle specific gene α7 integrin and sarcomeric sMtCK.

MyoD regulates HB-EGF (Heparin-binding EGF-like growth factor), a member of the EGF (Epidermal growth factor) family that stimulates cell growth and proliferation.[9] It plays a role in the development of hepatocellular carcinoma, prostate cancer, breast cancer, esophageal cancer, and gastric cancer.

MyoD can also bind to noncanonical E boxes of MyoG and regulate its expression.[28]

MyoG (Myogenin)[edit]

MyoG belongs to the MyoD transcription factor family. MyoG-E-Box binding is necessary for neuromuscular synapse formation as an HDAC-Dach2-myogenin signaling pathway in skeletal muscle gene expression has been identified.[29] Decreased MyoG expression has been shown in patients with muscle wasting symptom.[30]

MyoG and MyoD have also been shown to involve in myoblast differentiation.[31] They act by transactivating cathepsin B promotor activity and inducing its mRNA expression.

TCF3 (E47)[edit]

E47 is produced by alternative spliced E2A in E47 specific bHLH-encoding exons. Its role is to regulate tissue specific gene expression and differentiation. Many kinases have been associated with E47 including 3pk and MK2. These 2 proteins form a complex with E47 and reduce its transcription activity.[32] CKII and PKA are also shown to phosphorylate E47 in vitro.[33][34][35]

Similar to other E-box binding proteins, E47 also binds to the CANNTG sequence in the E-box. In homozygous E2A knock-out mice, B cells development stops before the DJ arrangement stage and the B cells fail to mature.[36] E47 has been shown to bind either as heterodimer(with E12)[37] or as homodimer(but weaker).[38]

Recent research[edit]

Although the structural basis for how BMAL1/CLOCK interact with the E-box is unknown, recent research has shown that the bHLH protein domains of BMAL1/CLOCK are highly similar to other bHLH containing proteins, e.g. Myc/Max, which have been crystallized with E-boxes.[39] It is surmised that specific bases are necessary to support this high affinity binding. Furthermore, the sequence constraints on the region around the circadian E-box are not fully understood: it is believed to be necessary but not sufficient for E-boxes to be randomly spaced from each other in the genetic sequence in order for circadian transcription to occur. Recent research involving the E-box has been aimed at trying to find more binding proteins as well as discovering more mechanisms for inhibiting binding.

Researchers at the Medical School of Nanjing University found that the amplitude of FBXL3 (F-box/Leucine rich-repeat protein) is expressed via an E-box.[40] They studied mice with FBXL3 deficiency and found that it regulates feedback loops in circadian rhythms by affecting circadian period length.

A study published April 4, 2013 by researchers at Harvard Medical School found that the nucleotides on either side of an E-box influences which transcription factors can bind to the E-box itself.[41] These nucleotides determine the 3-D spatial arrangement of the DNA strand and restrict the size of binding transcription factors. The study also found differences in binding patterns between in vivo and in vitro strands.

References[edit]

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^ Chaudhary, J; Skinner, M K. (May 1999). "Basic helix-loop-helix proteins can act at the E-box within the serum response element of the c-fos promoter to influence hormone-induced promoter activation in Sertoli cells". Mol Endocrinol. 13 (5): 774–786. doi:10.1210/mend.13.5.0271. PMID 10319327.

^ Ephrussi, A; Church, GM; Tonegawa, S; Gilbert, W (1985). "B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo". Science. 227 (4683): 134–140. Bibcode:1985Sci...227..134E. doi:10.1126/science.3917574. PMID 3917574.

^ Church, GM; Ephrussi, A; Gilbert, W; Tonegawa, S (1985). "Cell-type-specific contacts to immunoglobulin enhancers in nuclei". Nature. 313 (6005): 798–801. Bibcode:1985Natur.313..798C. doi:10.1038/313798a0. PMID 3919308. S2CID 1878459.

^ Murre, C; Mc Caw, P S; Vaessin, H; et al. (Aug 1989). "Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence". Cell. 58 (3): 537–544. doi:10.1016/0092-8674(89)90434-0. PMID 2503252. S2CID 29339773.

^ Henthorn, P; Kiledjian, M; Kadesch, T (1990). "Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif". Science. 247 (4941): 467–470. Bibcode:1990Sci...247..467H. doi:10.1126/science.2105528. PMID 2105528.

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^ Muñoz, Estela; Michelle Brewer; Ruben Baler (2006). "Modulation of BMAL/CLOCK/E-Box complex activity by a CT-rich cis-acting element". Molecular and Cellular Endocrinology. 252 (1–2): 74–81. doi:10.1016/j.mce.2006.03.007. PMID 16650525. S2CID 38180029.

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^ Nakahata, Y; Yoshida M; Takano A; Soma H; Yamamoto T; Yasuda A; Nakatsu T; Takumi T (January 2008). "A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes". BMC Mol Biol. 9 (1): 1. doi:10.1186/1471-2199-9-1. PMC 2254435. PMID 18177499.

^ Honma, S; Kawamoto, T; Takagi, Y; Fujimoto, K; Sato, F; Noshiro, M; Kato, Y; Honma, K. (2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock". Nature. 419 (6909): 841–844. Bibcode:2002Natur.419..841H. doi:10.1038/nature01123. PMID 12397359. S2CID 4426418.

^ Ripperger, J A.; Schibler, U. (Mar 2006). "Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions" (PDF). Nat. Genet. 38 (3): 369–374. doi:10.1038/ng1738. PMID 16474407. S2CID 13433446.

^ Prendergast, G C; Ziff, E B. (Jan 1991). "Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region". Science. 251 (4990): 186–189. Bibcode:1991Sci...251..186P. doi:10.1126/science.1987636. PMID 1987636.

^ Desbarats, L; Gaubatz, S; Eilers, M. (Feb 1996). "Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc". Genes Dev. 10 (4): 447–460. doi:10.1101/gad.10.4.447. PMID 8600028.

^ Xiao, Q; Claassen, G; Shi, J; Adachi, S; Seivy, J; Hann, S R. (Dec 1998). "Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis". Genes Dev. 12 (24): 3803–3808. doi:10.1101/gad.12.24.3803. PMC 317265. PMID 9869633.

^ Shklover, J; Etzioni, S; Weisman-Shomer, P; Yafe, A; Bengal, E; Fry, M. (2007). "MyoD uses overlapping but distinct elements to bind E-box and tetraplex structures of regulatory sequences of muscle-specific genes". Nucleic Acids Res. 35 (21): 7087–7095. doi:10.1093/nar/gkm746. PMC 2175354. PMID 17942416.

^ Bergstrom, D. A.; Penn, B. H.; Strand, A.; Perry, R. L.; Rudnicki, M. A.; Tapscott, S. J. (2002). "Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression". Mol. Cell. 9 (3): 587–600. doi:10.1016/s1097-2765(02)00481-1. PMID 11931766.

^ Tang, H; Goldman, D (2006). "Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade". Proc Natl Acad Sci USA. 103 (45): 16977–16982. Bibcode:2006PNAS..10316977T. doi:10.1073/pnas.0601565103. PMC 1636564. PMID 17075071.

^ Ramamoorthy, S; Donohue, M; Buck, M. (2009). "Decreased Jun-D and myogenin expression in muscle wasting of human cachexia". Am J Physiol Endocrinol Metab. 297 (2): E392–401. doi:10.1152/ajpendo.90529.2008. PMC 2724118. PMID 19470832.

^ Jane, D.T.; Morvay, L.C.; Koblinski, J.; et al. (2002). "Evidence that E-box promoter elements and MyoD transcription factors play a role in the induction of cathepsin B gene expression during human myoblast differentiation". Biol. Chem. 383 (12): 1833–1844. doi:10.1515/BC.2002.207. PMID 12553720. S2CID 26010667.

^ Neufeld, Bernd; Grosse-Wilde, Anne; Hoffmeyer, Angelika; Jordan, Bruce W. M.; Chen, Peifeng; Dinev, Dragomir; Ludwig, Stephan; Rapp, Ulf R. (7 July 2000). "Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity". Journal of Biological Chemistry. 275 (27): 20239–20242. doi:10.1074/jbc.C901040199. PMID 10781029.

^ Johnson, Sally E.; Wang, Xueyan; Hardy, Serge; Taparowsky, Elizabeth J.; Konieczny, Stephen F. (April 1996). "Casein kinase II increases the transcriptional activities of MRF4 and MyoD independently of their direct phosphorylation". Molecular and Cellular Biology. 16 (4): 1604–1613. doi:10.1128/MCB.16.4.1604. PMC 231146. PMID 8657135.

^ Sloan, Steven R.; Shen, Chun-Pyn; McCarrick-Walmsley, Ruth; Kadesch, Tom (December 1996). "Phosphorylation of E47 as a potential determinant of B-cell-specific activity". Molecular and Cellular Biology. 16 (12): 6900–6908. doi:10.1128/MCB.16.12.6900. PMC 231693. PMID 8943345.

^ Shen, Chun-Pyn; Kadesch, Tom (August 1995). "B-cell-specific DNA binding by an E47 homodimer". Molecular and Cellular Biology. 15 (8): 4518–4524. doi:10.1128/MCB.15.8.4518. PMC 230691. PMID 7623842.

^ Bain, Gretchen; Maandag, Els C.; Izon, David J.; Amsen, Derk; Kruisbeek, Ada M.; Weintraub, Bennett C.; Krop, Ian; Schlissel, Mark S.; Feeney, Ann J.; van Roon, Marian; van der Valk, Martin; te Riele, Hein P.J.; Berns, Anton; Murre, Cornelius (2 December 1994). "E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements". Cell. 79 (5): 885–92. doi:10.1016/0092-8674(94)90077-9. PMID 8001125. S2CID 34325904.

^ Lassar, Andrew B.; Davis, Robert L.; Wright, Woodring E.; Kadesch, Tom; Murre, Cornelius; Voronova, Anna; Baltimore, David; Weintraub, Harold (26 July 1991). "Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo". Cell. 66 (2): 305–15. doi:10.1016/0092-8674(91)90620-E. PMID 1649701. S2CID 25957022.

^ Murre, Cornelius; McCaw, Patrick Schonleber; Vaessin, H.; Caudy, M.; Jan, L.Y.; Jan, Y.N.; Cabrera, Carlos V.; Buskin, Jean N.; Hauschka, Stephen D.; Lassar, Andrew B.; Weintraub, Harold; Baltimore, David (11 August 1989). "Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence". Cell. 58 (3): 537–44. doi:10.1016/0092-8674(89)90434-0. PMID 2503252. S2CID 29339773.

^ Muñoz, E; Brewer, M; Baler, R. (Sep 2002). "Circadian Transcription: THINKING OUTSIDE THE E-BOX". J Biol Chem. 277 (39): 36009–36017. doi:10.1074/jbc.m203909200. PMID 12130638.

^ Shi, G; Xing, L; Liu, Z; et al. (2013). "Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock". Proc Natl Acad Sci U S A. 110 (12): 4750–5. Bibcode:2013PNAS..110.4750S. doi:10.1073/pnas.1302560110. PMC 3606995. PMID 23471982.

^ Gordân, R; Shen, N; Dror, I; Zhou, T; Horton, J; Rohs, R; Bulyk, ML. (Apr 2013). "Genomic Regions Flanking E-Box Binding Sites Influence DNA Binding Specificity of bHLH Transcription Factors through DNA Shape". Cell Rep. 3 (4): 1093–104. doi:10.1016/j.celrep.2013.03.014. PMC 3640701. PMID 23562153.

External links[edit]

E-Box+Elements at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

vteTranscription (Bacterial, Eukaryotic)Transcriptional regulationprokaryotic

Operon

lac operon

trp operon

gab operon

Gua Operon

ara operon

gal operon

Repressor

lac repressor

trp repressor

eukaryoticHistone-modifying enzymes(histone/nucleosome):

Histone methylation/Histone methyltransferase

EZH2

Histone demethylase

Histone acetylation and deacetylation

Histone deacetylase HDAC1

Histone acetyltransferase

DNA methylation:

DNA methyltransferase

Chromatin remodeling:

CHD7

both

Transcription coregulator

Activator

Coactivator

Corepressor

Inducer

Promotion

Promoter

Pribnow box

TATA box

BRE

CAAT box

Response element

Enhancer

E-box

Response element

Insulator

Silencer

Internal control region

Initiation

Bacterial

Eukaryotic

Archaeal transcription factor B

Elongation

bacterial RNA polymerase: rpoB

eukaryotic RNA polymerase: RNA polymerase II

Termination(bacterial, eukaryotic)

Terminator

Intrinsic termination

Rho factor

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Encyclopedia of Cancer pp 1201–1204Cite as

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Encyclopedia of Cancer

Reference work entry

E-Box

Britta Mädge2

Reference work entry

First Online: 01 January 2017

238 Accesses

Synonyms

E-box; E motif

Definition

E-box is the collective term for DNA motifs with the consensus sequence CANNTG. E-boxes appear in a broad variety of promoters and enhancers and serve as protein-binding sites. Proteins with affinity to this motif belong to the basic helix-loop-helix (bHLH) class of transcription factors, which can act as activators of transcription as well as repressors. More than 240 bHLH proteins are known to date in eukaryotes ranging from yeast to human, and the number continues to grow. Their binding specificity depends on both the nature of the “NN” nucleotides and sequences in the vicinity of the E-box. Genes containing E-boxes are activated during important developmental processes and some are described to be involved in cancer development and/or progression.

Characteristics

The DNA sequence “CAGGTGGC” was originally identified in 1985 within the sequence of the immunoglobulin enhancers, the first enhancers found to be activated in a tissue-specific manner....

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ReferencesMurre C, McCaw PS, Baltimore D (1989) A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777–783Article

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Ellenberger T, Fass D, Arnaud M et al (1994) Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev 8:979–980Article

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Atchley WR, Fitch WM (1997) A natural classification of the basic helix-loop-helix class of transcription factors. Proc Natl Acad Sci USA 94:5172–5176Article

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Massari ME, Murre C (2000) Helix-loop-helix proteins: regulators of transcription in eukaryotic organisms. Mol Cell Biol 20:429–440Article

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Download referencesAuthor informationAuthors and AffiliationsDKFZ, Heidelberg, GermanyBritta MädgeAuthorsBritta MädgeView author publicationsYou can also search for this author in

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Britta Mädge .Editor informationEditors and AffiliationsUniversity Professor of Genetics, German Cancer Research Center - DKFZ, Heidelberg, GermanyManfred Schwab Rights and permissionsReprints and permissionsCopyright information© 2011 Springer-Verlag Berlin HeidelbergAbout this entryCite this entryMädge, B. (2011). E-Box.

In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_1795Download citation.RIS.ENW.BIBDOI: https://doi.org/10.1007/978-3-642-16483-5_1795Published: 10 March 2017

Publisher Name: Springer, Berlin, Heidelberg

Print ISBN: 978-3-642-16482-8

Online ISBN: 978-3-642-16483-5eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life SciencesShare this entryAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard

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